Thursday, October 31, 2019

To what extent was the final solution planned Essay

To what extent was the final solution planned - Essay Example While some people believe that this was a spontaneous decision made by Hitler, others believe that the process was systematically planned. The aim of this paper is to find out how far the Final Solution was planned. The investigation will cover what the Final Solution was, the debate of the decision, the extermination camps, and to what extent it was planned. It was right around 1942 when the plans of the Final Solution fully took hold, but over one million Jews had already been murdered. â€Å"It was only with the decision to eradicate the entire Jewish population that the extermination camps were built and industrialized mass slaughter of Jews began in earnest. This decision to systematically kill the Jews of Europe was made by the time of or at the Wannsee Conference, which took place in Berlin, in the Wannsee Villa on January 20, 1942. During the conference, there was a discussion held by a group of German Nazi officials to decide on the ‘Final Solution of the Jewish Question’† (Wikipedia 2008, p. 1). The extent to which the Final Solution was planned can be proven by documents that contain the minutes and other records of the Wannsee Conference. The Allies located these documents at the end of World War II and used them as evidence in the Nuremberg Trials. â€Å"The records and minutes of this meeting were found intact by the Allies at the end of the war and served as valuable evidence during the Nuremberg Trials. â€Å"By spring of 1942, Operation Reinhard began the systematic extermination of the Jews, although hundreds of thousands already had been killed by death squads and in mass pogroms. In Heinrich Himmlers speech at the Posen Conference of October 6, 1943, Himmler, for the first time, clearly elucidated to all assembled leaders of the Reich, in frank and brutal terms, what the "Final Solution" referred to† (Wikipedia, 2008, p. 1). The Final Solution was the Nazi’s plan to

Tuesday, October 29, 2019

Multicultural Education (7) Coursework Example | Topics and Well Written Essays - 1250 words

Multicultural Education (7) - Coursework Example What surprised me about multicultural education is that the cultural background of a teacher and students can affect the learning process. According to Salili and Hoosain (2001), "Teachers and students alike have their own cultural backgrounds, values, customs, perception and prejudices. These cultural characteristics play an important role in teaching and learning situations and can have substantial effects on our learning and behavior" (p. 9). The fact that some teachers may harbor prejudiced opinions on learners is surprising to me. In my opinion, a teacher ought to expect the best of his or her students regardless of their cultural backgrounds. Salili and Hoosain (2001) reiterate that methodical investigations conducted in the past have shown that teachers beliefs about their students have an impacts on performance. A good example as cited by Salili and Hoosain (2001) is the fact that some may have stereotypes that African American students perform poorly as compared to White Ame rican students. The new insights I have had as a result of this class include the importance of conducting proper training to teachers on multicultural education before they can train students. It is important for teachers to have optimistic mindsets in regard to cultural differences characteristic of their students. Being considerate and respectful of different cultural aspects especially in regard to religion and race can have an effect on the overall performance of the students in the classroom (Ghosh, 2011). My main challenge was in relation to communication barrier. Language according to Salili and Hoosain (2001) is one of the factors that define cultures. It is difficult to communicate to students or people whose language is different from mine. As an example , a Chinese student will have to learn English if he wishes to enroll in an American school. However, accent can still be a challenge for teachers. Students performance is dependent on whether the

Sunday, October 27, 2019

Competitive Analysis Of Porters Five Forces Model

Competitive Analysis Of Porters Five Forces Model 1. Competitive Analysis of Porters Five-Forces Model Porters Five Forces model is a widely used approach to determine the strength of the competitive forces that will influence a company. (Exhibit1) The competitive pressures that Robert Mondavi faces in the U.S. domestic wine industry based on Porters Five-Forces Model are described below: 1.1. Bargaining Power of Suppliers RMC has used backward integration strategy to increased control of grape suppliers. He has successfully convinced many of Krugs top grape suppliers to sign long term contract with RMC for approximately 75% of its purchases. (Professor Roberto, 2002) He also worked closely with each grower to improve grape quality and the contract has been structured where the compensation was tied to the grape quality crop yields. This will improve the stability of the price as most of the growers depend on RMC for sustenance, thus give them very little bargaining power over RMC. Mondavi also convinced Krugs top two suppliers to take financial stake in his new winery. (Silverman, Gilinsky, Guy Baack, 2001) Since now they are the stakeholders have long term contractual relationship with Mondavi, it has reduced the likelihood that suppliers will increase price. Furthermore, RMC has invested more than $50mil over the past 10 years to replant vineyards after the phylloxera epidemic. For long-term plan, Mondavi also acquired additional vineyards to increase its internal grape sourcing to 25% by 2005 so that his wineries wont rely heavily on independent growers. (Professor Roberto, 2002) As such, threat of supplier bargaining power is low for RMC as they attempt to control the suppliers operations right from production to distribution. 1.2. Bargaining Power of Customers Sales of wine in U.S. are mainly controlled by three-tier distribution system. RMC sells wines to their customers who are the wholesalers/distributors, who then provided wines to local retails businesses which accounted for 78% of total sales volume in U.S. Supermarkets alone have contributed 52% of retails wine sales. (Silverman, Gilinsky, Guy Baack, 2001) However major changes had taken place in wholesale and retail wine business. Number of alcoholic beverage distributors had decreased by 75% in early 1960s and substantial market share are now controlled by top 5 distributors. (Exhibit 2) As a result, large distributors are enjoying economies of scales and prefer to distribute only top selling wine brands since the product can be replenished quickly. Bargaining power of distributors had increased significantly since they have a lot of wine brands to choose from. Furthermore, five new world countries Australia, Canada, Chile, New Zealand and U.S. have signed trade agreement in 2001 to keep markets open and reduce trade barriers. (Castaldi, Cholette, Hussain, 2006) With the globalization of wine industry, a lot of international wine brands are eyeing for space on the store shelves of these few powerful supermarkets. As a result, RMC faced increasing competition as they relied heavily on top distributors retails chain for domestic sales, which accounted for two-third of its revenue. (Professor Roberto, 2002) As a result, bargaining power of customers is high for RMC 1.3. Potential Entry of New Competitors Consolidation is occurring among wineries worldwide through merges and acquisitions in wine industry. In 1970s, several food and beverage conglomerates, like Nestle and Coca-Cola have entered premium market by acquiring premium to ultra-premium wineries. In 1980s, global alcoholic beverage companies, like Canandaigua and The Wine Group have acquired wineries to complement their beer distilled spirits businesses. In 1990s, there were some 200 new wineries in the Napa Valley competed with RMC in premium market. (Silverman, Gilinsky, Guy Baack, 2001) A growing number of these wineries were nearly owned by multinational companies which have free-flow of cash and able to gain economic of scales in wine industry through merger or requisition strategy. Furthermore, they have substantial investment in working capital and funding to acquire new vineyards or even pay higher prices for grape supplies. Although RMCs skills expertise are difficult to imitate, but the knowledge and experience of these new competitors in alcoholic beverage industry with the support of their existing distribution assets will be an added advantage for them to compete in wine industry. As a result, the new competitors with huge capital have dwindled capital resources of RMC, which ended in public listing to obtain more capital to compete and take advantage of future opportunities (Silverman, Gilinsky, Guy Baack, 2001) As such, threat of new competitors is high for RMC especially when the big companies treat mergers and acquisitions as attractive ways to grow. 1.4. Rivalry among Competing Firms Rivalry among competing firms is often the strongest of the five competitive forces especially in U.S. wine industry, which was composed of approximately 1,500 wineries with the top 10 accounting for 70% of U.S. production. (Silverman, Gilinsky, Guy Baack, 2001) RMC has experienced intense rivalry from few dominant large volume producers like EJ Gallo Winery and Canandaigua Wine which have controlled 40-50% of market share (Exhibit 3). Furthermore, EJ Gallo also start to enter the premium wine segment aggressively to capitalize on changes in consumer demand toward premium wines. This will affect RMC which is primarily competing for premium wine market. Besides, large volume producer like EJ Gallo also gained economies of scale and have been viewed as sales powerhouse by many industry observers. They adopted strategy of substantial vertical integration by owning glass container manufacturer, bottle cork operation, lime quarry, a fleet of trucks and network of distribution centres throughout the country. (Professor Roberto, 2002) This enabled Gallo to enjoy a significant cost advantage. In this situation, rivalry is more likely. Furthermore, most of the rivalries have focused on channels promotions strategy to increase brand awareness and broaden its customer base in the premium market. They employed a direct sales force, organize wine competitions, wine tourism as well as wine testing and education activities at their vineyard to build the publics awareness. To sustain the competitiveness, RMC has gone far with the launched of its first radio television advertising campaign nationwide. As such, rivalry among competing firms is high for RMC in premium wine segment. 1.5. Potential Development of Substitute Products There are a lot of categories in alcoholic beverage industry such as beer and distilled spirits. When considering substitute for wine, many people will always think the wine substitute is beer. Actually all these are more of a compliment than substitute as each product has its own characteristic, can be differentiated and used to accompany different occasion. However the threat of substitute products is moderately high for RMC within the wine category. For example, an incident happened in 1999 where all the distributors began to substitute competing Chardonnay brand on retailers shelves after RMC experienced shortfall in supplying Woodbridge Chardonnay brand. (Silverman, Gilinsky, Guy Baack, 2001) Furthermore, there are a lot of wines with similar price, taste quality are readily available from local or multinational brands. The wide selection of wines has confused the customers during the buying process and always have trouble to remember which wines they bought and liked. (Castaldi, Cholette, Hussain, 2006) As a result, the brand loyalty of customers is low and switching to an alternative product is more likely during the purchase process. Although RMC has presence in all premium categories and hold a competitive advantage in economic of scales and price, but the threat of substitute products is still possible as most of the distributors only prefer to buy the wines which gained most awards and acclaim from wine enthusiasts. Finally based on Porters Five Forces, it can be concluded that only threat of suppliers are favorable to RMC. Due to the high competitive and continuous threats from new entrance such as alcoholic beverage companies, it is important for RMC to be more innovative in developing world-class wines in order to sustain the domestic economic profits. 2. Key Success Factors of the Wine Industry 2.1. World Renowned Growing Area U.S., a new world producing country in wine industry was composed of approximately 1,500 wineries. The most famous growing area is California, which are the top wine producer in U.S. and fourth leading wine producer in the world behind the countries like France, Italy and Spain. (Wine Institute.org, 2007) The uniqueness of California is the ideal climate, topography, and soil condition which enable RMC to produce premium wines that are able to compete with the premium European brands. Besides, California also attracted a lot of tourists throughout the year. Hence, it continuously provides a constant source of customers to RMC. 2.2. Modern Winemaking Facilities Technologies Wine industry is a capital intensive industry and requires great winemaking techniques facilities to produce high quality wines. Based on the study by Professor Roberto (2002), RMC operated six wineries in California and each of these wineries employed modern technology to insure the gentle handling of grape and the high quality of fermentation and aging processes. Besides, RMC also built a state-of-art winemaking facility and assembling a team of experts in the area of viticulture and winemaking. All these new techniques and development of experts have been an added advantage for RMC in the production of world-class premium wines. 2.3. Domestic Market Growth Potential U.S has a very strong domestic market for wine industry due to its status of fourth largest producer of wine and third largest consumer in 1999. (Exhibit 4 5) Based on the study by Castaldi, Cholette, Hussain (2006), the highest concentration of table wine consumers was aged between 35 to 55 and 31.4% of consumption contributed by the adults in families earning over $75,000 annually. Normally this group of people has a very high disposable income and willing to pay more for premium wine. As a result, RMC is able to leverage on this favorable demographic to enjoy both economies of scale in the growing premium market. Those adults who are not regular wine consumers consist of teetotalers and beer or spirit supporters. (Castaldi, Cholette and Hussain, 2006) There are a lot of potential to convert this group of beer purchasers to become wine consumers. It can be done via innovative marketing strategy, e.g. health benefits related to moderate wine consumption. In conclusion, many project that U.S. will become the worlds largest wine market by 2008 with the steady rise of per-capita consumption in recent years. (Exhibit 5) 2.4. Focus in building Portfolio of Premium Wine Segment RMCs strategy is to focus on the premium wine segment. With the introduction of Woodbridge brand wine in the popular premium super-premium categories, it has become the best seller wine and contributed more than half of the RMCs revenue in 1999. To further broaden its customer base, RMC has introduced few new brands via domestic diversifications and global partnerships to fill various price points in the premium wine segment. RMC also further divided the ultra-premium category into two categories, which has not been adopted by the industry to-date. (Silverman, Gilinsky, Guy Baack, 2001) This strategy enables RMC to consistently produce premium wines to reach different group of customers and further differentiates their products from competitors, which focus more on jug wines. As a result, RMC able to sustain the competitiveness in U.S. wine industry. 2.5. Globalization of Wine Industry In 2001, U.S. wine industry has gone into globalization with the signing of Mutual Acceptance Agreement (MAA) on Oenological (winemaking) Practices with four new world countries, Canada, Australia, Chile and New Zealand. The main purpose is to promote greater international wine commerce and eases trade barriers for U.S. wine. (Wine Institute.org, 2007) This enables RMC to sell their product outside the region with lower tariffs, logistic cost and trade barriers. As a result, RMC has increasingly look abroad to increase sales, earnings and take advantage of certain macro-economic factors such as exchange rates. It also gives an opportunity for RMC to showcase other wines to enhance its reputation in international markets. 3.1 Steps to ensure the Success of Strategy Implementation Robert Mondavi future business strategy is to form global join ventures as a way to develop world-class wine and transform RMC to become a truly global company that grow, produce and sell wines in all the best wine-growing regions in the world. (Silverman, Gilinsky, Guy Baack, 2001) To ensure the success of strategy implementation, RMC need to focus on below few areas: 3.1.1. Positive Cash Flow Successful strategy implementation always requires additional capital. Based on the RMC Financial Statement (FY1997-1999), although the revenue has increased from $300.80 millions to $370.60 millions, but the net profit margin has reduced significantly from 9.4% in FY1997 to 8.3% in FY1999 (Exhibit 6). Therefore, it is very important for the company to recover its financial position by further pay down its debt in order to generate more free cash flow. In addition, it will provide more financial resource for RMC to grow its portfolio by taking advantage of future opportunities. 3.1.2. Market Segmentation Product Positioning With the plan to venture globally, it is very important for RMC to determine the characteristic and needs of consumers as well as analyze consumer similarities and differences in every new market. As consumers are different in every country, RMC needs to produce different wines to meet different country preference. With market segmentation, it will enable RMC to position each of its wines appropriately to meet consumer needs and expectation. As a result, RMC will have better control on production, distribution and advertising for each of its wine. Finally, it will help RMC to improve operation efficiency and hence maximizing the profits. 3.1.3. Traditional Online Advertising Campaign To conquer the global market, it is extremely important for RMC to build its brand and broaden its customer base. Based on the study by Professor Roberto (2002), most of the premium wineries in U.S. do not spend much on consumer advertising. They tended to focus more on channel promotion. As such, it poses a large opportunity for RMC to strengthen its brand appearance in advertising medium. For example, RMC can focus on TV and radio advertising to build trust and emotional connection with consumers. RMC can also advertise in selected premium magazines to strengthen its premium market penetration. Furthermore, with the emerging of new online medium, it will also help RMC to reach those consumers who are difficult to reach via traditional media. In conclusion, advertising is an important tool for brand building. 3.1.4. Management Operations Control Strategy implementation will never success without the strong management and operations control. RMC needs to establish clear, reasonable, measurable and achievable annual objectives which are well communicated throughout an organization. With clear annual objectives, all the employees will have the same understanding and moving towards the same direction in implementing the strategy. It will also help in allocating resources more efficiently according to annual objectives and provide relevant training for each employee to further enhance their skills. Besides, performance-linked rewards must be well placed to motivate and improve the productivity of all employees. Lastly, adequate and timely evaluation is needed to ensure the performance conform to the strategy. 3.2. Potential Problems during the Strategy Implementation 3.2.1 Conflict between Employees Conflict might occur between two or more parties in RMC. Normally misunderstanding disagreement occur during the implementation process as each party has their own commitments and expectations to achieve. Conflict is unavoidable for all organizations especially for RMC which has a large workforce to manage. For example, in 1999 Michael Mondavi was caught between the 2 camps due to an argument for RMCs future strategy. (Silverman, Gilinsky, Guy Baack, 2001) As such, conflict need to be solved before negative consequences affect the organizational performance and strategy implementation. 3.2.2. Resistance to Change Resistance to change is another potential problem that RMC might face during the strategy implementation. People fear to change because any changes in structure and strategies will affect or disrupt the current working environment. However, continuously adapt to changes is necessary for RMC to compete in the fast growing and increasingly competitive wine industry. Normally those organization best adapt to the changes will gain significant competitive advantage and strategy implementation can be relatively easy. 3.2.3 Challenge of Financial Management Monetary Systems RMC might face a challenge to maintain its financial stability over the next few years as strong financial budgets capital are required to sustain the business worldwide. Furthermore, RMC will also deal with two or more exchange rates which can complicate its global operation. The global profitability will also affected by the direct impact from dollar when the economy slowdown.

Friday, October 25, 2019

Comparing Low-fat, Low-calorie, and Low-carbohydrate Diets Essays

Comparing Low-fat, Low-calorie, and Low-carbohydrate Diets Low-fat, low-calorie, and low-carbohydrate diets are of unequal effectiveness and merit. Low-carbohydrate diets are simply better. All three diets attempt to induce weight loss by managing the body’s energy intake. The body gets the energy it needs to stay alive from food. Food can be broken down into three major categories: carbohydrates, protein, and fat. Even though fat contains the most calories per gram, because of the way digestion works, the body gets all of its energy from carbohydrates and none from fat found in food. When the body takes in excess energy, it is stored in body fat. If it ever needs to, the body can dip into these energy reserves by breaking down the fat in which the energy is stored. Low-carbohydrate diets work by cutting back on the body’s main fuel source, carbohydrates, and replacing it with fat and protein. While protein and fat have other vital uses in the body, they do not provide any energy. So, the body is forced to burn fat for fuel. Lo w-calorie diets simply proscribe a lower overall caloric intake thereby providing the body with insufficient fuel, again forcing the body to dip into its reserves. Low-fat diets reduce fat intake because proponents of low-fat diets claim that fat is the type of food with the biggest caloric bang for its nutritional buck Low-fat diets are based on the fallacious connection between body fat and fat in food. There is no such connection, and this is a mistake that can have dire consequences. The body does not use fat as an energy source. People actually gain weight on low-fat diets because snacks toted as low-fat are frequently high in carbohydrates to compensate for the loss of flavor from lack of fat. Becau... ...st in calories. However, that connection is nonexistent and people can gain weight on low-fat diets if they are not careful. They also do not get enough of the vitamins that are only found in fat. Low-calorie diets stipulate a cutback in overall food intake. Such diets are effective but also cut back on essential vitamins. By reducing the amount of carbohydrates in a persons diet and replacing them with fat and protein low-carbohydrate diets safely and efficiently induce weight loss. Works Cited 1. Astrup, Anne, Thomas Meinert Larsen, and Angela Harper. Atkins and other low carbohydrate diets: hoax or an effective tool for weight loss. www.thelancet.com Vol. 364. September 4, 2004. 2. Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry. 3rd ed. Worth Publishers. 2000 3. http://www.weightlossforgood.co.uk/fat_information.htm

Thursday, October 24, 2019

American Film History 1930-60

The chief technological innovation during the 1930s was the development of deep focus cinematography. Deep focus involved the expansion of depth of field, resulting in images that maintained sharp focus from objects in the extreme foreground to those in the distant background. Deep focus was achieved by filming with extremely wideangled lenses whose apertures had been stopped down. This sort of cinematography was made possible by a variety of developments in related fields of film technology.In 1939 the introduction of lens coatings, which permitted 75 per cent more light to pass through the lens to the film inside the camera, enabled cinematographers to decrease the lens aperture an additional stop, facilitating greater image definition. The results of these developments can be seen in Orson Welles’ Citizen Kane (1941). This and other films which were shot in exteriors took advantage of relatively short focal-length lenses and abundant sunlight to produce ‘deep' images. According to this new code, the film stock's greater sensitivity to the full range of colours signified a greater realism.On Citizen Kane the Toland style is most pronounced, most systematically and effectively employed, and most widely recognized. Although he had been refining his methods in the films with Wyler and Ford, Toland had yet satisfactorily to combine his technical and stylistic interests within a single picture. He saw Citizen Kane as a chance to experiment on a large scale. In a June 1941 article in Popular Photography entitled â€Å"How I Broke the Rules on Citizen Kane†, Toland related that ‘the photographic approach †¦was planned and considered long before the first camera turned', which was itself ‘most unconventional in Hollywood', where cinematographers generally have only a few days to prepare to shoot a film. Robert L. Carringer, in his indepth sudy of the production, writes that Welles and Toland ‘approached the film together in a spirit of revolutionary fervor', and that ‘Welles not only encouraged Toland to experiment and tinker, he positively insisted on it' (Nowell-Smith 45). The work indicated something of a shift to a more documentary-style realism.Citizen Kane was, then, an opportunity for Toland to make flamboyant deep focus identified with his own work. Welles had come to Hollywood with no professional film experience, and (according to Welles) Toland had sought out the Kane assignment. After the filming was completed, Toland was at pains to claim several innovations. For greater realism, he explained, many sets were designed with ceilings, which required him to light from the floor. Since the sets were also deep, he relied on the carrying power of arc lamps.Furthermore, since Welles and Toland had decided to stage action in depth, Toland sought great depth of focus by using Super XX film, increasing the lighting levels, and using optically coated wide-angle lenses (Bordwell 45). The result s hifted the traditional limits of deep space. In yielding a depth of field that extended from about eighteen inches to infinity, Toland's ‘pan-focus' made it possible to have a sharp foreground plane in medium shot or even close-up and still keep very distant background planes in focus. Fifty years on, Kane remains contentious.French critic Andre Bazin, who saw it in 1946 at the same time as Italian neo-realism, argued that its extensive use of deep focus promoted the reality of the phenomenal world of the film, but subsequent critics have noted that the film is also highly self-conscious, artificial, and even baroque. The use of deep focus was not unique, and director of photography Gregg Toland had already experimented with it on other productions. Welles's role as ‘author' of the film has also been hotly contested, notably by Pauline Kael (1974), who argued, probably incorrectly, that the script was solely the work of Herman J.Mankiewicz. But even if Kane was not compl etely novel in its structures or techniques, it remains the fact that these techniques are masterfully integrated in the film's complex texture. Bazin, for example, argued that Citizen Kane was a film of high quality in that it was a film of realism. Realism was an axiom of his aesthetic position. But the statement which links this axiom with the specific aesthetic judgement of Citizen Kane raises problems. The realism of the film, Bazin argues, derives from its use of deep-focus photography and minimal cutting.Such techniques minimize fragmentation of the real world. The trouble is that this could be a definition of realism as nonfragmentation, or an assertion that films employing such techniques are perceived as more real. The latter, unlike the former, is open to empirical test, although Bazin uses it as a selfevident aesthetic judgement. Thus, although there is nothing inherently wrong with the argument, it does involve different sorts of statements with consequent different cri teria of adequacy.Bazin does share a considerable admiration for the achievements of Italian neo-realism; in particular. And yet Bazin rarely falls into the trap of seeming to formulate a puritan aesthetic which will include neo-realism at the expense of all else. Unlike Kracauer (formally, at least) he admits to different forms of realism. Thus, for example, the distinction he draws between the ‘documentary' realism of Scarface and the ‘aesthetic' realism of Citizen Kane, both forms allegedly finding their unification in La Terra Trema (Bordwell 90).This willingness to speak of different types of realism can lead to problems in interpreting his position. In Signs and Meaning in the Cinema, Wollen takes to task two contemporary inheritors of Bazin's views (Barr and Metz) over their opposition of Rossellini and Eisenstein. The villain for Bazin, he points out, was not Eisenstein, but German Expressionism. But the real problem is that at different times, and in different w ays, Bazin occupies both positions. He starts life invoking a case similar to Kracauer's in favour of a ‘purist' realism.But this proves too limiting for his much more catholic tastes, and so he also develops a second case as spatial realism. Unfortunately, he never really brings the two conceptions face to face; never really resolves the strains between them. It seems useful here to take a closer look at these basics of his argument: The realism of the cinema follows directly from its photographic nature. Not only does some marvel or some fantastic thing on the screen not undermine the reality of the image, on the contrary, it is its most valid justification.Illusion in the cinema is not based as it is in the theatre on convention tacitly accepted by the general public; rather, contrariwise, it is based on the inalienable realism of that which is shown. All trick work must be perfect in all material respects on the screen. The `invisible man' must wear pyjamas and smoke a cig arette (Bazin 108). Andre Bazin puts Welles in his pantheon of realist directors, along with Renoir, Rossellini, De Sica, Stroheim, Flaherty, and even Murnau (whom he praises for choosing the moving camera over editing in the construction of many of his filmic scenes).Yet Citizen Kane is also a film in the tradition of German Expressionism. Like Murnau, Welles externalized the subjectivity of his characters (and especially of Kane) by means of psychologically charged settings, acute camera angles, distorting lenses, and disconcerting camera movements (Tudor 56). The demented architecture of Xanadu in the mist-enshrouded shots at the beginning of the film recalls Howard Hawks’ Scarface (1932). Near the end of the film both Susan and Kane are dwarfed by the oversized ornaments and statuary that furnish Xanadu, and serve as external projections of Kane's inner deadness and mindless materialism.The gargantuan rooms through which their voices echo—they nearly have to shout at each other to be heard—reflect the distance that has grown between them. When Kane steps into an enormous blazing fireplace and informs Susan that â€Å"Our home is here,† he metaphorically becomes the host of hell. After Susan leaves him, Kane, now utterly alone, wanders past a structure of double reflecting mirrors which reflect his image into infinity. As far as he looks, all he can see are images of himself, a perfect physical representation for a man trapped within his own narcissism.Welles also used extreme camera angles and strange camera movements in conjunction with his expressive mise-en-scene. In the year of its release, Citizen Kane was a radically experimental film—fully twenty years ahead of its time—and was widely recognized as such by American critics. Citizen Kane is surely the most celebrated and analyzed of all English language films and, arguably, the greatest – at least as measured by periodic surveys of critics and scholars . We saw that in the 1940s a realist aesthetic somewhat modified classical practice. This was conceived as partly an ‘objective' verisimilitude, especially of setting and lighting.Location shooting, taken in conjunction with low-key (‘mood') lighting, helped define one distinct postwar cinematographic practice. This practice did not fundamentally violate classical principles of causal and generic motivation. This conception of ‘realism' also owed something to a standardization of deep-focus shooting. Certain traits became common to many ‘realistic' films of the 1940s and 1950s. Finally, Bazin sees both forms of realism in spatial realism of Welles. Certainly Citizen Kane preserves the unity of space through Toland's deep-focus photography.Certainly the cuts are minimized by use of dissolves and joins across the soundtrack. But Welles is, nevertheless, the true inheritor of expressionism, the specialist in the distortion by camera angle, the mysterious shadows once painted but now created through lighting, the grotesque, and the baroque. Works Cited Bazin, Andre, What is Cinema? op. cit. Bordwell, David, The Classical Hollywood Cinema: Film Style & Mode of Production to 1960. Routledge: London, 1988. Nowell-Smith, Geoffrey The Oxford History of World Cinema. Oxford University Press: Oxford, 1997. Tudor, Andrew, Theories of Film. Viking Press: New York, 1974.

Wednesday, October 23, 2019

Enzyme Inhibition

Enzyme Inhibition Many drugs exert their action by inhibition of an enzyme activity in the body. If the activity of an enzyme is vital to the cell or organism, then inhibition may lead to death of the cell or organism. It is now possible to design new drugs which are enzyme inhibitors once a target enzyme has been identified. Types of Inhibitors A) Reversible Inhibitors:  The effect of the inhibitor is instantaneous, and it can be removed from the enzyme by dialysis so that the enzyme activity is returned to normal.Such inhibitors interact with the enzyme by weak non-covalent bonds to form an enzyme inhibitor complex. E + I ? EI B) Irreversible Inhibitors:  These inhibitors bind very tightly to the enzyme, sometimes by formation of covalent bonds to form an enzyme inhibitor compound rather than a loose complex. The effect is therefore progressive with time reaching a maximum when all of the enzyme has reacted. This is not easily reversed by simple physical treatments such as dial ysis. E + I > EI Reversible Inhibition of EnzymesThere are three types of reversible enzyme inhibition;  competitive, non-competitive  (also called mixed)  and uncompetitive. Competitive- molecules which closely resemble the substrate in size, shape and charge distribution may also slip into the active site. This may result in reaction i. e. the second molecule is another substrate for the enzyme, or it may result in inhibition because the active site is blocked. The inhibitor has a separate equilibrium with the enzyme. The binding of substrate and inhibitor is mutually exclusive. E + S ? ES > E + P, E + I ?EI Each of these equilibria is characterised by a dissociation constant. The first by Km (the Michaelis constant) and the second by Ki which characterises the binding between enzyme and inhibitor. If sufficient [S] is present then eventually the inhibition by I will be overcome. This is the diagnostic test for this type of inhibition. Both I and S compete for the available enzyme. The activity of an enzyme is described by the following equation: (Michaelis- Menton equation) In the presence of a  competitive reversible inhibitor, this equation becomes;So the  Michaelis constant  (which is a reciprocal measure of affinity of E and S) is changed by the factor 1 + [I]/Ki where [I] is the inhibitor concentration and  Ki is the dissociation constant for the equilibrium between E and I. Most importantly,  Vmax is unchanged  Ã¢â‚¬â€œ this is diagnostic for this type of inhibition. Ki is best defined as the concentration of inhibitor required to slow the reaction to half the rate it shows in the absence of inhibitor. It is a reciprocal measure of the affinity of E and I. Lineweaver-Burk Plot for Competitive Reversible InhibitionThe  intercept on the y axis represents 1/Vmax. The slope is altered by the factor 1 + [I]/Ki, but the  easiest way to calculate Ki  is from the  ratio of the intercepts on the x axis. Without inhibitor the intercept is -1//Km, with inhibitor it is -1/Km(1+[I]/Ki), so the ratio (bigger over smaller so it is greater than 1) is 1 + [I]/Ki. Easiest way to calculate Ki  is from the  ratio of the intercepts on the x axis. Equation: Other Types of Reversible Inhibition Uncompetitive- This type of reversible inhibition is said to occur when the inhibitor binds with the enzyme-substrate complex rather than the enzyme.Substrate and inhibitor bind dependently. Noncompetitive (Mixed)- This type occurs when the inhibitor binds to both the enzyme and enzyme-substrate complex. Substrate and inhibitor bind independently. Irreversible Inhibition of Enzymes Reversible  means that the timescale of the inhibition is similar to that of the enzyme action, usually measured over a few minutes. Irreversible  means that the enzyme activity is inhibited for times significantly longer than the assay times for the enzyme. It does not necessarily mean that the inhibition will not reverse given sufficient time i. . hours, days or weeks. Some of the most interesting examples of enzyme inhibitors as drugs are those which fall between the two extremes and are sometimes defined as Quasi-Irreversible. These include tight-binding inhibitors, transition state analogues and slowly dissociating intermediates. Tight-Binding inhibitors  and  Transition State Analogues  form high affinity complexes with the enzyme and may have Ki values in the order of nanomolar (10-9  mol L-1). The value of Ki will be very important in describing the potency of this type of inhibitor.As a rough guide the inhibitor concentration causing 50% inhibition (I50) is used as a measure of Ki. Slowly Dissociating Intermediates  react with the enzyme to form covalent intermediates which take time to dissociate from the enzyme. A Classification of Enzyme Inhibitors as Drugs For a compound to work as a drug in vivo it will ideally have TWO very important properties. These are; Potency  To work in vivo as an enzyme inhibit or the inhibitor will need to be potent enough so that the dose required is in the order of milligrams to grams.Specificity  If a compound is a nonspecific enzyme inhibitor it is more likely to be toxic and exhibit serious side effects. It may be a poison. Simple Reversible- A simple reversible inhibitor binds to the enzyme and decreases the enzyme activity instantaneously and reverses within the time of the enzyme action. The inhibitor binds non-covalently (ionic interactions, hydrogen bonds, Van Der Waal's forces) to the enzyme and the strength of binding is of a similar order to the substrate i. e. Ki will be of similar size to Km. For very good reasons, the Km values for enzymes vary between about 10-2  mol L-1  to 10-6mol L-1.Unlikely to be potent enough to work in vivo where competition occurs in a dynamic metabolic situation. For a simple competitive inhibitor the inhibition will be self-limiting. If an enzyme is not rate limiting, it may be necessary to achieve ;90% in hibition before any increase in substrate concentration occurs. To do this the inhibitor concentration needs to be approximately 20 times the Ki value. Conformationally Restricted Competitive Inhibitors- It is possible that a reversible competitive inhibitor which is a conformationally restricted analogue of the substrate will have a much higher affinity for the enzyme han does the substrate and hence can be potent enough to work in vivo at reasonable concentrations. Such compounds may have Ki values in the region of 1 x 10-7  mol L-1 Quasi-Irreversible Tight Binding Inhibitors- This is an extension of the previous class i. e. competitive inhibitors which are conformationally restricted and/or have many non-covalent interactions leading to long lasting complexes. Therefore binding is very tight (Ki in order of 10-9  mol L-1  to 10-10  mol L-1) and these compounds are potent enough to act as drugs in vivo.Transition State Analogues- Theoretically, an analogue of a transition state (or reaction intermediate) for the enzyme catalysed reaction will bind much tighter than an analogue of the substrate. The outcome is a potent and potentially specific inhibitor. Theoretically, Ki values can be very low. In practice if Ki values in the region of Nano molar can be achieved, these are potent enough to work in vivo. As we shall see, there has been much work in this area on proteases including HIV protease and there are now a major class of drugs which has been developed on this principle.Slowly Dissociating Intermediates- Some enzymes form covalent intermediates as part of their mechanism e. g. acetylcholinesterase. It is possible for a compound to act as a pseudo-substrate and be converted into a long lasting intermediate. Such an inhibition is time dependent and in some cases is virtually irreversible. Sometimes the intermediate is hydrolysed in minutes or hours but this is still much longer than the normal enzyme mechanism when the intermediate would last only milliseconds. Examples include the anticholinesterases neostigmine and physostigmine (eserine) and penicillin.Irreversible Nonspecific: a. Heavy metal poisons e. g. cyanide, hydrogen sulphide, carbon monoxide- Some enzymes and other important proteins such as Haemoglobin and Cytochromes, require metals as cofactors. These metals are often transition metals such as Fe, Cu, Mn, Zn and ligands which are electron rich will form co-ordinate covalent bonds with these metals will inactivate these proteins. These bonds are strong and very often these ligands are toxic because of this irreversible inactivation.Cyanide reacts with cytochrome oxidase which is the terminal electron carrier in the electron transport chain by ligand formation with the Cu atom at the centre of its mechanism. Similarly, carbon monoxide complexes with the Fe atom in the haem cofactor of haemoglobin. b. Heavy metal ions e. g. mercury, lead etc. – These are common irreversible inhibitors because of their abili ty to complex firmly with particular groups in enzymes. These effects can be reversed by treatment with chelating agents such as EDTA (ethylene di-amino tetra acetic acid). c. Thiol poisons e. . alkylating agents, Arsenic (III) Many enzymes contain thiol (-SH) groups in amino acid side chains – cysteine, which are essential for catalytic activity. Any compound which reacts with these functional groups will poison the enzyme. E. g. Iodoacetamide  (alkylating agent) Arsenic- The most toxic form of Arsenic is As (III) as in arsenite AsO2. In this form, Arsenic reacts rapidly with  thiol groups, especially with dithiols such as lipoic acid which is an essential cofactor for some important enzymes such as pyruvate dehydrogenase and -ketoglutarate dehyrdrogenase.You should remember these enzymes as part of the link reaction and the citric acid cycle. When these enzymes are blocked, respiration stops. Arsenic derivatives have been prepared as very poisonous war gases e. g. Lewis ite. antidote called  Dimercaprol (‘British Anti-Lewisite')  was designed by incorporating two thiols for the poison to react with. The two thiol groups react with the arsenical war gas forming a stable compound and thus stopping it from blocking the thiol groups in lipoic acid. Dimercaprol  is used these days as an antidote to poisoning with heavy metals such as antimony, arsenic, mercury, bismuth, gold, thallium.It is also used in conjunction with pencillamine in the treatment of lead poisoning (see BNF). Specific Irreversible Inhibitors: Affinity Labels (Active site directed irreversible inhibitors)- An analogue of the substrate which binds to the active site of an enzyme, but which contains a chemically reactive group, has the potential to form covalent bonds with side chains at or near the active site. These inhibitors are irreversible and have been very useful in elucidating enzyme mechanisms but their reactive nature makes them likely to be toxic when used in vivo .Mechanism-based Inhibitors (‘suicide reagents') – The principle of this sort of inhibition is that a pseudo substrate is accepted by the enzyme which then catalyses the production of its own inhibitor which reacts covalently in the active site. Such inhibitors should be specific as well as potent. Certain monoamine oxidase inhibitors have this mechanism, also the -lactamase inhibitors (e. g. clavulanate). The pyridoxal phosphate (vitamin B6) dependent enzymes have been a particular candidate for the development of this kind of inhibitor (e. g. difluoromethyldopa). Enzyme inhibitors:Edrophonium – conformationally restricted competitive reversible, ACE inhibitors – Tight binding, HIV protease inhibitors – Transition state analogues, Neostigmine, Penicillin – Slowly dissociating intermediates DFP – Irreversible group specific reagent, Clavulanate – mechanism-based irreversible inhibitor. Types of Enzyme Inhibitors Simple Reversibl e| Competitive (also uncompetitive, noncompetitive, mixed)| Simple substrate analogues Michaelis-Menten kinetics Ki in region of Km i. e. 10-2  Ã¢â‚¬â€œ 10-6  M| Restricted Conformation| Rigid shape similar to favoured substrate fit Ki less than Km| e. g. drophonium as inhibitor of acetylcholinesterase| Quasi-Irreversible| Tight Binding Ki can be in region of nanomolar| E. g. ACE inhibitors Captopril, enalapril etc. | | Transition State Analogues. Binding constant theoretically below nanomolar| Inhibitors of proteinases e. g. pepsin, renin, HIV proteinase| | Slowly Dissociating Intermediates – time dependent kinetics| e. g. neostigmine, eserine as anticholinesterases Penicillin| Irreversible| Heavy metal poisons etc| Cyanide, Hydrogen Sulphide, Carbon Monoxide| | Group reagents| e. g. Arsenic (III), Iodoacetamide| | DFP action on esterases| | Affinity labels| TPCK on Chymotrypsin| | Mechanism Based (‘suicide inhibitors')| e. g. Clavulanate onlactamase| Enzyme Inhibi tors as Drugs ENZYME| INHIBITOR(S)| USES| Acetylcholinesterase| Edrophonium Neostigmine Eserine| Myasthenia Gravis Glaucoma Paralytic Ileus| Monoamine Oxidase| Tranylcypramine| Depression| Xanthine Oxidase| Allopurinol| Gout, adjunct to Cancer chemotherapy| Carbonic Anhydrase| Acetazolamide| Diuresis| Dihydrofolate Reductase| Methotrexate| Leukaemia|Transpeptidase| Penicillin| Antibacterial| Cyclo-oxygenase| Aspirin etc. Non-steroidal anti-inflammatory drugs| Analgesia Anti-inflammatory Anti-platelet| Angiotensin Converting Enzyme (ACE)| Captopril, enalapril, lisinopril etc. | Anti-hypertension| Thymidylate Synthetase| Fluorouracil| Cancer chemotherapy| Penicillinase (-lactamase)| Clavulanate etc| Anti-bacterial| HIV proteinase| Saquinovar etc| HIV treatment| Reverse Transcriptase| AZT| HIV treatment| HMG-CoA Reductase| Statins, pravastatin etc. | Coronary Heart Disease| Phospodiesterase V| Viagra| Erectile dysfunction|

Tuesday, October 22, 2019

Relationship Between Fiction and Non-fiction

Relationship Between Fiction and Non-fiction Free Online Research Papers Fiction and non-fiction are both very intriguing types of writing to read. Many people view them as total opposites. The fiction stories are usually very funny and made up, but they can be very informative if put in the right context. Non-fiction stories can be used to tell readers of personal losses or gains. One can take a piece of non-fiction writing and place it within a fiction text’s context, which makes the writing serve a new purpose. By placing non-fiction into fiction text, the writing is transformed from a piece of analysis into a tool of the fiction’s text. There are many instances where stories are written with a good mix of fiction and non-fiction. When stories are written with a bit of each type of writing they are more informational and use more examples. Even though the two are perceived as opposites, they actually go hand in hand when trying to get a point across. There are times in fiction writing where there are references to non-fiction ideas. Some writers do this for a comparison of things that aren’t possible. There are many novels, short stories, fables, fairy tales, films, comics, interactive fiction, animation, and video games that can include or reference factual occurrences. Fiction is the written expression of, reflection upon, and/or interpretation of observed, perceived, or recollected experience just like non-fiction. An example of this would be in the fiction story â€Å"Lottery† that tells of people going to a lottery and the â€Å"winner† gets killed by stones. The reason this story related to non-fiction is because it described the occurrences in towns in previous years. In non-fiction writing there is usually a lot of facts placed within the story’s text. There are a lot of other times where fiction is included in the non-fiction work because of a similarity between the idea the fiction has and the one nonfiction has. The non-fiction stories use factual references such as â€Å"Oh, this is the wrong bitch?† (141) and â€Å"Young Franklin Deland Roosevelt attended Groton, as did boys with last names like DuPont, Morgan and Harriman† (143) to give emotion and to make the story sound good by having a famous person involved. Non-fiction stories usually relate to personal issues such as losses or gains just as fiction uses humor to represent opinions. There is also the fact that both fiction and non-fiction try to resemble real-life occurrences to help stop or encourage others to do certain things. The way that fiction and non-fiction are expressed really helps people understand concepts. When people read a story that has a mix of the two types of writing, they are able to learn from other people’s doings and sometimes get a laugh also. When fiction is placed within the text of the non-fiction it helps with the understanding of the text. The way that fiction writing can be used to describe real life occurrences is interesting to many people. It is usually very important for people to read both fiction and non-fiction texts to understand the similarities and differences between both. Research Papers on Relationship Between Fiction and Non-fictionHonest Iagos Truth through DeceptionMind TravelBook Review on The Autobiography of Malcolm XThe Masque of the Red Death Room meaningsRelationship between Media Coverage and Social andThree Concepts of PsychodynamicTrailblazing by Eric AndersonThe Fifth HorsemanHarry Potter and the Deathly Hallows EssayStandardized Testing

Monday, October 21, 2019

What Do Passovers 4 Questions Have to Do with Our Modern Lives

What Do Passovers 4 Questions Have to Do with Our Modern Lives Passover started last Monday night and I was fortunate enough to attend a lovely seder (traditional Passover meal) with a family here in Madison. What especially impressed me was that they were open to discussing the contemporary implications of the traditional â€Å"four questions† (which are actually one question followed by four answers). The Four Questions Why is this night different from all other nights? On all other nights we eat leavened products and matzah [unleavened, cardboard-like â€Å"bread†], and on this night only matzah. On all other nights we eat all vegetables, and on this night only bitter herbs. On all other nights, we dont dip our food even once, and on this night we dip twice. On all other nights we eat sitting or reclining, and on this night we only recline. The explanation for each of the four items goes something like this: We eat matzah because the bread on the backs of the Jews fleeing Egypt did not have enough time to rise. The bitter herbs remind us of the bitterness of slavery in Egypt. Dipping karpas (potato, onion, or other vegetable) into saltwater reminds us that the joy of spring was tempered by the tears we cried while in Egypt. Similarly, the charoset (fruit-nut paste) into which the bitter herbs are dipped reminds us of the cement we used to create the bricks in Egypt. Again, a mix of sweetness and bitterness. Reclining like â€Å"royalty† is a way to commemorate our freedom. Now you might be saying, Thanks for the lesson in Jewish religion, but what does any of this have to do with business or job search activities? Well, let me tell you. The Four Questions in Our Modern Lives Remembering the matzah means remembering that if we rush around without giving ourselves time and space for our bread to rise, we will end up with a cardboard life. It’s the equivalent of sending out a mediocre resume or blindly taking action in a business without stepping back to strategize and consider the implications of those actions. Will we get results? Sure. But maybe not the robust ones we’re hoping for. It’s important during Passover to actually EAT matzah, not just avoid leavened food. Why? Because if we don’t eat the unleavened bread we will forget not to eat leavened food. It’s like saying Oh, I’ll remember to call x person back but not putting it on the calendar, then realizing at the end of the day that it never happened. Or saying I won’t spend 3 hours on Facebook today but failing to put any structures in place to make that happen. If we don’t eat the matzah- if we don’t create a structure for remembering- we are in danger of forgetting and falling into our routine lives. Does this ring true for you? We all have bitter moments to remember in our lives. We have been rejected for our dream jobs. We have had clients asking for refunds. We have made poor, often costly decisions. We have had great ideas that bombed. It’s important to remember the bitterness of those moments, even as we move on into freer and more successful times. We will then appreciate our successes more and have greater perspective when things take what seems like a bitter turn. On Passover we dip a symbol of new growth into a symbol of sadness, then dip something bitter into something sweet yet representative of pain. Perhaps we dip twice because if we only dipped once we would forget. Forget how growing pains are not just something we have as children, but a fact of life for anyone committed to their own personal development. Forget that every move forward requires letting go of the way it was before. A new job might mean saying goodbye to trusted colleagues or spending less time at home with the kids. Taking on more leadership might mean leaving a comfort zone that was, well, comfortable. Life is a mix of bitter and sweet always, and if we forget, if we start expecting it to be some other way, we are likely to become even more bitter. The commandment to recline like royalty is a great reminder to take care of ourselves and allow ourselves to be taken care of. It means taking a break from rushing around without allowing time for the bread to rise. Whatever it represents for you, consider in this season giving yourself the gift of luxuriating just a little in the abundance and joy that surrounds you. I would love to hear your interpretation of Passover or Easter themes and how they relate to your personal or professional lives. Please share!

Sunday, October 20, 2019

Alexander Fleming Discovers Penicillin

Alexander Fleming Discovers Penicillin In 1928, bacteriologist Alexander Fleming made a chance discovery from an already discarded, contaminated Petri dish. The mold that had contaminated the experiment turned out to contain a powerful antibiotic, penicillin. However, though Fleming was credited with the discovery, it was over a decade before someone else turned penicillin into the miracle drug that has helped save millions of lives. Dirty Petri Dishes On a September morning in 1928, Alexander Fleming sat at his workbench at St. Marys Hospital after having just returned from a vacation at the Dhoon (his country house) with his family. Before he had left on vacation, Fleming had piled a number of his Petri dishes to the side of the bench so that Stuart R. Craddock could use his workbench while he was away. Back from vacation, Fleming was sorting through the long unattended stacks to determine which ones could be salvaged. Many of the dishes had been contaminated. Fleming placed each of these in an ever-growing pile in a tray of Lysol. Looking for a Wonder Drug Much of Flemings work focused on the search for a wonder drug. Though the concept of bacteria had been around since Antonie van Leeuwenhoek first described it in 1683, it wasnt until the late nineteenth century that Louis Pasteur confirmed that bacteria caused diseases. However, though they had this knowledge, no one had yet been able to find a chemical that would kill harmful bacteria but also not harm the human body. In 1922, Fleming made an important discovery, lysozyme. While working with some bacteria, Flemings nose leaked, dropping some mucus onto the dish. The bacteria disappeared. Fleming had discovered a natural substance found in tears and nasal mucus that helps the body fight germs. Fleming now realized the possibility of finding a substance that could kill bacteria but not adversely affect the human body. Finding the Mold In 1928, while sorting through his pile of dishes, Flemings former lab assistant, D. Merlin Pryce stopped by to visit with Fleming. Fleming took this opportunity to gripe about the amount of extra work he had to do since Pryce had transferred from his lab. To demonstrate, Fleming rummaged through the large pile of plates he had placed in the Lysol tray and pulled out several that had remained safely above the Lysol. Had there not been so many, each would have been submerged in Lysol, killing the bacteria to make the plates safe to clean and then reuse. While picking up one particular dish to show Pryce, Fleming noticed something strange about it. While he had been away, a mold had grown on the dish. That in itself was not strange. However, this particular mold seemed to have killed the Staphylococcus aureus that had been growing in the dish. Fleming realized that this mold had potential. What Was That Mold? Fleming spent several weeks growing more mold and trying to determine the particular substance in the mold that killed the bacteria. After discussing the mold with mycologist (mold expert) C. J. La Touche who had his office below Flemings, they determined the mold to be a Penicillium mold. Fleming then called the active antibacterial agent in the mold, penicillin. But where did the mold come from? Most likely, the mold came from La Touches room downstairs. La Touche had been collecting a large sampling of molds for John Freeman, who was researching asthma, and it is likely that some floated up to Flemings lab. Fleming continued to run numerous experiments to determine the effect of the mold on other harmful bacteria. Surprisingly, the mold killed a large number of them. Fleming then ran further tests and found the mold to be non-toxic. Could this be the wonder drug? To Fleming, it was not. Though he saw its potential, Fleming was not a chemist and thus was unable to isolate the active antibacterial element, penicillin, and could not keep the element active long enough to be used in humans. In 1929, Fleming wrote a paper on his findings, which did not garner any scientific interest. 12 Years Later In 1940, the second year of World War II, two scientists at Oxford University were researching promising projects in bacteriology that could possibly be enhanced or continued with chemistry. Australian Howard Florey and German refugee Ernst Chain began working with penicillin. Using new chemical techniques, they were able to produce a brown powder that kept its antibacterial power for longer than a few days. They experimented with the powder and found it to be safe. Needing the new drug immediately for the war front, mass production started quickly. The availability of penicillin during World War II saved many lives that otherwise would have been lost due to bacterial infections in even minor wounds. Penicillin also treated diphtheria, gangrene, pneumonia, syphilis, and tuberculosis. Recognition Though Fleming discovered penicillin, it took Florey and Chain to make it a usable product. Though both Fleming and Florey were knighted in 1944 and all three of them (Fleming, Florey, and Chain) were awarded the 1945 Nobel Prize in Physiology or Medicine, Fleming is still credited for discovering penicillin.

Saturday, October 19, 2019

Assighment Essay Example | Topics and Well Written Essays - 1000 words

Assighment - Essay Example All this will indeed be a challenge for me but utilizing the gained knowledge will help me overcome the challenges and make the store a profit center. Discussion What are the most significant challenges facing you as manager of this store? For me as the manager, the most significant challenges can be enumerated as follows: Low volume of Sales: As the manager of the store, the most important thing for me to keep the store afloat would be the finances. The store cannot operate at a loss and to ensure that it is not at a loss, sales are the most important criteria. The store will have certain fixed overheads and certain variables. Fixed overheads include salaries, electricity, rent, telephone expenses etc. These are the costs the store has to bear even if there is no sale. These components are discounted by the profit which is generated out of sales. In the event of no or low sale, the fixed expenses stand as it is and proves heavy for the store. Variable expenses also are a part of exp enses which are incurred in case of sale. Suppose freight charges for delivery of products etc. So this cost is only incurred if there are sales and is directly proportionate to sales. So in case, there is low sale, my store will have to bear the fixed overheads at least. There needs to be a minimum amount of sale to cover the fixed costs and be at zero profit at least(Berman, 2007). Manpower issue: Since the store is not doing well, the manpower cannot be more due to their costs. The plus point here is that the store has a good blend of experienced and fresh manpower. So to utilize maximum potential from them, the experienced ones should provide some training to the fresh ones and always back them up during sales. The attrition rate also has to come down to save on training time and cost. Branding and Advertising: Since the store once enjoyed loyalty of customers in neighborhood, the goodwill re-building would not be so difficult. I should focus on how I can harness the goodwill al ready built among certain groups of people to attract them to be our customers at the shopping mall and to promise them that the quality of products and services are same irrespective of change of hands of the store. What steps would you take during the first 90 days as manager to address these challenges? In the first 90 days, the steps I would take have been described below: Since the employees include high school and college students, I would harness their contacts to boost my sales. I would plan an incentive for each employee if they give me a minimum amount of business. Example: An employee will be offered x% of the sales value if they give a minimum of x amount of business. Since they are college students, offering only a small amount will be enough to motivate them to bring in business. This will be done keeping in mind the profitability of business. Once we have customers, they can be converted to repeated customers later on through schemes and good service. Specifically aim ed promotion: The store needs to be promoted in such a way that the people who were already loyal customers can connect to the promotion activities and believe that the store is still the same as they liked it even after change of hands. The erstwhile loyal customers will be the first ones whom I would like to be my customers as they will be easy to convince. Once they are back, word-of-mouth will play

Friday, October 18, 2019

MLA Formatting and Style Guide by Purdue OWL Essay - 10

MLA Formatting and Style Guide by Purdue OWL - Essay Example For instance, in case of expert users, the document needs to present facts through the use of figures and any available data, there is no need of definitions, explaining the data, background explanations and the writer can use abbreviations. This is different for writing other documents because one needs to explain things like terms, the user data and focus on the bigger picture. Visuals are important in the sense that they enhance the meaning of the document and easily create an understanding to the user on what the document is all about. Visuals play a significant role in attracting the attention of the end user to a particular document and help them multitask when reading a technical document. Visuals keep the user interested because they easily connect to the document. Training manuals are the choice of a technical communication document to use in my field. The document will be used to enhance classroom teaching by the professor and helps students understand better the subject at hand. The documents target students in institutions of higher learning and it’s best suited compared to any other technical communication document.

Email for Prescription for control system Coursework

Email for Prescription for control system - Coursework Example er relevant budgets that need to be prepared to analyze the movement of costs are: production budget; raw materials and purchasing budget; as well as labor budget (Agriculture and Consumer Protection, n.d.); 4. The production budget should contain the following the following information where the budget is â€Å"expressed in quantitative terms only and is geared to the sales budget. The production managers duties include: (a) analysis of plant utilization; and (b) work-in-progress budgets. If requirements exceed capacity he may: (i) subcontract; (ii) plan for overtime; (iii) introduce shift work; or (iv) hire or buy additional machinery† (Agriculture and Consumer Protection, n.d., p. 1); 5. The raw materials and purchasing budget should be evaluated in the light of factors that could influence and affect these, including production requirements; planning stock levels; storage space; and trends of material prices (Agriculture and Consumer Protection, n.d.). 6. The labor budget, finally, must be analyzed in terms of the following factors that influence and affect the costs: production requirements; man-hours available and used; grades of labour required; wage rates (union agreements); and the need for incentives (Agriculture and Consumer Protection, n.d.). 10. These costs should therefore be monitored on a regular basis, say monthly, quarterly and annually, against the budgets prepared to determine the factors influencing them and to institute the required courses of action to control and manage these costs. In response to your proposal to purchase an offset press to print manuals, instead of purchasing them from local print shops, please be advised that to enable management to decide on its feasibility and viability, the following information would be required for comprehensive and effective review: 2. The installation cost to be incurred should be determined. Some suppliers incorporate the cost of installation to their quotation price for the equipment. Since

Youth Leadership and Devcelopment as a Social Movement Essay

Youth Leadership and Devcelopment as a Social Movement - Essay Example A survey done by The Search Institute whose findings have been accumulated in a book "A Fragile Foundation: The State of Developmental Assets among American Youth" has identified 40 assets or building blocks classified into 08 categories required for a healthy development of a child, many of which were found missing in the life of an American child. As a result, an average American child is building his life on a fragile foundation resulting in their problematic behavior. The first four asset categories focus on external structures, relationships and activities that create a positive environment for youth and include loving and caring support from family, friends and teachers, a feeling of being valued and having clear-cut rules about the expected behavior and consistent consequences of breaking them, to be and do their best, opportunities outside of school to learn and develop new skills and interests with other youth and adults. The next four categories reflect internal values, ski lls and beliefs that young people need to fully engage with and function in the world around them and include commitment to learning and a belief in their own abilities, having strong guiding values or principles to help them make healthy life choices and having Social Competencies to interact effectively with others, to make difficult decisions and to cope with new situations. They also need to believe in their own self-worth and to feel that they have control over the things that happen to them. As American society was found miserably lacking in providing their youth an environment suitable for their young ones to flourish in, there is an urgent requirement of augmenting the efforts on the scale of a national movement and already more than 300 communities have started initiative to mobilize resources and motivate all sectors of the community to help build those building blocks required for the well-being of our young generation. One of the most effective ways to the positive development of our youth as envisaged by many organizations which are sincerely working in this direction is through channelizing youthful energy in community building work. This programme for Youth leadership and Development works on the principle of considering youth as an asset to themselves and shifts its stress from youth's needs and problems and lays it on considering them as a powerful tool to tackle societal evils..According to them as pure human capital in community ventures, youth offer tremendous and often untapped contributions. Young people's exuberance and optimism alone can make rich additions to efforts to strengthen communities. Yet all too often youth are seen only as heirs to the future, trustees of posterity who will in some distant future finally take their place as partners in civic life. For many community organizations and programs, youth are underused resources, overlooked and marginalized. However, those organiz ations and projects that do involve young people as integral and respected leaders and participants, are not only enriching their endeavors, they are also exercising a powerful and promising strategy for youth development. The Innovation Center for Community and Youth development, a project of the Tides Center, a non-profit organization dedicated to supporting people working for social change is working in strategic partnership with key individuals and institutions and with youth and adult staff and volunteers who share a devotion to the potential of

Thursday, October 17, 2019

Goodfellas Movie Review Example | Topics and Well Written Essays - 750 words

Goodfellas - Movie Review Example In this essay I will be looking at how Goodfellas conforms to the Hollywood tradition of using the film noir style in conveying a gangster story, as well as how it differs from the tradition. The story begins by showing a Brooklyn kid's desire to be a gangster as a respected means to the American Dream; a life choice no different from wanting to be a fireman. Of course the boy's parents did not agree and he was starting fires, not putting them out. This was the movies first difference from the film noir approach. This is more light-hearted than usually portrayed by film makers of crime dramas. The story goes on to tell of how the boy forewent normal school to learn the dos and don'ts of the mob. Although crime was definitely shown in Goodfellas, it was presented as being rewarding and mutually beneficial to all involved. It was presented as an opportunity open to anyone smart enough to get involved. That included crossing guards, truck drivers and cops. The narrator referred to it as glories times. Presenting crime with crossing moms from the elementary school, not just rough looking bad guys, reinforced the lighter touch to a crime drama. There was strong comedy included in the beginning and continued throughout the film. When violence was depicted there was a break in the action, often a pause, not to prolong the violence but to somewhat soften the impact or shock value. As most movies do, the music played a memorable role in presenting the scene. The music gave an upbeat to the movie. The songs if heard on the radio will bring the movie to mind. Often in traditional film noir the music catered drama and suspense to the movie. In the tradition of film noir the Goodfellas appealed the public's fascination with criminals and their life style. Goodfellas, is the story of Henry Hill, his family, and associates. Because facts in the story are verifiable, the fascination to the movie was stronger. The main character, Henry Hill was portrayed as a goodfella who simply sold a "little" drugs, cheated a "little" on his wife, lied a "little" to those who trusted him, stole as much as he could, but never really hurt anyone. So he really was not a bad guy. This allowed the audience to give him favor and want to see him come out unscathed. These things were excepted behavior. For most of guys in the movie, killing got to be accepted. Henry never spoke of or was shown killing anyone, which again is not normal film noir style. Another avenue most gangster movies explore is one of cultures. Whether it is an Italian, Irish, Puerto Rican, Mexican, Jamaican, or African gang, cultural differences and traditions are always addressed. Culture was included as part of the traditional film noir style. In this film it was Italian and Irish cultures. It was mentioned throughout the movie to explain a deeper meaning of different scenes. Centered in most gangster movies that follow the film noir style are conflicts involving self interest, morality, legality and the very thin line drawn between them. Goodfellas was not an exception to this rule. This was the theme of the movie. From beginning to the end the narrator spoke of what was acceptable in protecting one's own interest and the interest of the mob. His first pinched was celebrated because he did not rat on his friends. Paulie understood what was done while in prison to

Wednesday, October 16, 2019

The Impact of the Automobile on Society Research Paper

The Impact of the Automobile on Society - Research Paper Example From the discussion it is clear that in 1895, during a newspaper interview, Thomas Edison, an American inventor, stood at the edge of time and gazed into the horizon. They saw a future of unbounded potential in which the horseless carriage would reign. They added that it would only a question of time before their prophecy happened. At the time, many would have dismissed Edison as an idle dreamer. Carriages driven by horses were the main means of transportation then. As one would suspect, these were pricey and a preserve of the rich. Today, over a century after Thomas Edison pronounced their prophecy, the automobile is the dominant means of movement. This paper examines the impact of the automobile on society at a global scale. By the term "automobile" is meant widest scope to include public transit and heavy commercial vehicles.This paper declares that  the modern car was born in 1886 when Karl Benz, a German inventor, built the Benz Patent-Motorwagen. However, the car had to wait until the early 1900s to become widespread. Ford Motor Company’s Model T was one of the earliest cars to be produced en masse for the public. In the United States, cars rapidly replaced carriages and carts drawn by animals. Soon afterward, there were about ten thousand cars on American roads. It had taken much longer before cars were embraced in Europe and elsewhere in the world. The commencement of production of cars on a large scale by Henry Ford in 1914 ushered in an era of ever-increasing affordability for the automobile.

Goodfellas Movie Review Example | Topics and Well Written Essays - 750 words

Goodfellas - Movie Review Example In this essay I will be looking at how Goodfellas conforms to the Hollywood tradition of using the film noir style in conveying a gangster story, as well as how it differs from the tradition. The story begins by showing a Brooklyn kid's desire to be a gangster as a respected means to the American Dream; a life choice no different from wanting to be a fireman. Of course the boy's parents did not agree and he was starting fires, not putting them out. This was the movies first difference from the film noir approach. This is more light-hearted than usually portrayed by film makers of crime dramas. The story goes on to tell of how the boy forewent normal school to learn the dos and don'ts of the mob. Although crime was definitely shown in Goodfellas, it was presented as being rewarding and mutually beneficial to all involved. It was presented as an opportunity open to anyone smart enough to get involved. That included crossing guards, truck drivers and cops. The narrator referred to it as glories times. Presenting crime with crossing moms from the elementary school, not just rough looking bad guys, reinforced the lighter touch to a crime drama. There was strong comedy included in the beginning and continued throughout the film. When violence was depicted there was a break in the action, often a pause, not to prolong the violence but to somewhat soften the impact or shock value. As most movies do, the music played a memorable role in presenting the scene. The music gave an upbeat to the movie. The songs if heard on the radio will bring the movie to mind. Often in traditional film noir the music catered drama and suspense to the movie. In the tradition of film noir the Goodfellas appealed the public's fascination with criminals and their life style. Goodfellas, is the story of Henry Hill, his family, and associates. Because facts in the story are verifiable, the fascination to the movie was stronger. The main character, Henry Hill was portrayed as a goodfella who simply sold a "little" drugs, cheated a "little" on his wife, lied a "little" to those who trusted him, stole as much as he could, but never really hurt anyone. So he really was not a bad guy. This allowed the audience to give him favor and want to see him come out unscathed. These things were excepted behavior. For most of guys in the movie, killing got to be accepted. Henry never spoke of or was shown killing anyone, which again is not normal film noir style. Another avenue most gangster movies explore is one of cultures. Whether it is an Italian, Irish, Puerto Rican, Mexican, Jamaican, or African gang, cultural differences and traditions are always addressed. Culture was included as part of the traditional film noir style. In this film it was Italian and Irish cultures. It was mentioned throughout the movie to explain a deeper meaning of different scenes. Centered in most gangster movies that follow the film noir style are conflicts involving self interest, morality, legality and the very thin line drawn between them. Goodfellas was not an exception to this rule. This was the theme of the movie. From beginning to the end the narrator spoke of what was acceptable in protecting one's own interest and the interest of the mob. His first pinched was celebrated because he did not rat on his friends. Paulie understood what was done while in prison to

Tuesday, October 15, 2019

Marketing 4p assigment Essay Example for Free

Marketing 4p assigment Essay INTRODUCTION 1. 0 BACKGROUND OF THE ORGANIZATIONS: Backed by more than 20 years of experience in Japan, Sushi Zanmai possesses extensive expertise for raw materials selection. Base on the nature of Business is classified as Food Beverage industry. The purpose of their business is serves the best food and services to each customers. Genuine ingredients coupled with original recipes and original taste, they provide more than 100 assortments of sushi and 100 varieties of cooked food that are authentically Japanese. They now have 10 outlets in Malaysia which is at Sunway Pramid, One Utama, Garden Mall, Low Yat Plaza, Paradigm Mall, Fahrenheit 88 and 1 Month Kiara. They have their own wedsite for customers more easily to find out the most nearby location and know what is new on that month. The main selling product is sushi other that they also have sell noodles, rice set, desserts, and beverages. That sushi of colour plate starts from RM1. 80. 2. 0 THE PRODUCT OF SUSHI ZANMAI Sushi Zanmai is originated from Japan. They are offering the combination of tangible goods and services in their business. They provide traditional Japanese foods and services on their business. They business are on direct sell foods to customers. They have serves appetiser which the Japanese meal begins with a visual feast of chilled and warm appetisers, like: Salmon roe Japanese omelette Potato Mayonnaise Sushi Zanmai created own specialties featuring the freshest, handpicked ingredients provide a fresh, contemporary spin on much-loved favourites, exquisitely tailored to suit local taste preferences such as, Sanshoku Hana Salmon Caterpillar Roll Wasabillar Roll The traditional entree consists of expertly-sliced raw fish, shellfish or mollusks, complemented perfectly by the combination of wasabi and soy sauce, and often accompanied by pickled ginger, example Salmon sashimi Toro sashimi Maguro sashimi According to survey, most of the female prefer sushi salad that the reason Sushi Zanmai products include various types of Salad to let customers choose too. As you can see the three popular salad dishes are Sashimi Salad Salmon Salad Kaiso to Tofu Salad Rolled sushi in Japanese language is pronounces maki. It usually comprises of seafood which may or may not be raw, vinegared rice and paper-thin seaweed. For example, Salmon Maki Soft Shell Crab Maki Natto Maki Follow that, they do have Temaki. The â€Å"te† in Temaki means hand is Japanese language. The Temaki sushi is two- fold. It not only refers to a hand roll that is made entirely with the hand, without the traditional bamboo mat. The cone-shaped Temaki sushi is ofeten prepared as an appetizer. Soft Shell crab Temaki Ikura Temaki Unagi Temaki Other than that, noodles are also usually customers will order it. They have provide three types of noodles one is soba which is made from wheat flour, Udon made from wheat flour, Ramen made from Chinese wheat flour and served with a wide range of soup stocks such as soy-sauce base and salt base. Sansai Udon Niku Ramen Kakaiage soba Donburi a dishes consist of a deep bowl of rice topped off with chicken, beef or seafood cooked in a variety of styles and sauces. They have, Curry Rice Unadon Ebidon In beverages, they served many types of drinks like Green Tea, Calpis Smoothies, fine Japanese Sake, Soft Drinks, Japanese Plum Wine and others. Green Tea (unlimited refill) Ichigo Smoothies Choya Extreme A dessert to end the meals. It have multiple choice as well as, Macha Macha Parfait Itachoco Monaka Stawberry Parfait For the level of the product and services, Sushi Zanmai is selling the product which is categories in actual product. They have their own brand name, design, packaging that deliver the core benefit to customers. They are selling high quality level product that most of the ingredients are import from Japan such as Salmon, tuna, sea bream, Eel and etc. Besides, Sushi Zanmai are selling the shopping product goods which is one of the important consumer goods in market. There have few reason because of Sushi Zanmai’s product is belong to shopping product. Sushi Zanmai of products is consumers purchase and consume on a less frequent schedule compared to convenience products. Normally, they opened their business inside the shopping mall and which is high class and crowded shopping mall. They will do more selective when choosing distribution outlets to sell their products. However, customers are willing to spend more time locating their products since they are relatively more expensive than convenience products and because these may process additional psychological benefits for the purchaser, such as raising customers status level within their social group. 3. 0 THE PRICING STRATEGY THAT USED BY SUSHI ZANMAI Sushi Zanmai has successfully follows the price skimming strategy when setting the price of its products. The price skimming strategy allows Sushi Zanmai to charge a price that is above the competition, but also promote frequent sales to lower the price below them. Different groups of customers are willing to pay different prices for the same product. Sushi Zanmai can sell â€Å"The Extreme† to the customers who will pay the higher price to be the first to buy and also to the bargain hunters. Finally, this strategy will emphasize the product and service quality. Sushi Zanmai sets a high initial price for its products to send a signal to customers that its products are quality and the service is excellent. Next, Sushi Zanmai also using price line and price bundle as the pricing strategies. Product Line Pricing They have selling same product of food but different categories. Every guest has different taste and love different type of cruise that the reason Sushi Zanmai has to classify as well. Certainly, different materiel of food sure is different price charging. For example: Sushi Name Ingredients Price Inari Sakura Shiitake fish floss RM3. 80 Kaki Fry Roll Friend oyster sushi roll topped with mayonnaise RM9. 80 Dragon Roll Fried prawn sushi roll topped with avocado RM12. 80 Rice Name Ingredients Price Ebidon Deep fried prawn with egg on rice RM8. 80 Chiken Katsu Curry Chicken cutlet and rice with curry sauce RM10. 80 Unadon Roasted eel on rice RM15. 80 Noodles Name Ingredients Price Tsukimi Udon or ramen noddles with egg RM6. 80 Sansai Udon or soba noodle with vegetables RM8. 80 Curry Udon or ramen noodle with chicken curry RM10. 80 Product Bundle Pricing Sushi Zanmai has offering set promotion to attract more guests to purchase their products. Set promotion is type of bundle strategy. It can let guests feel the price is lower or cheaper but just have in certain and limited lime for it, like: Chicken Keraage Don and ice lemon tea for only RM7. 90 As manager will be considered in a few points when setting the bundle pricing strategy: Customer demands, sort out which is the product of the guests prefer or like it. Customers always pursue cheaper price, Target profit; make sure will reach the target. 4. 0 PLACE OF SUSHI ZANMAI Location is very important to those in Food and Beverage industry, as the product they sell is shopping product, the customers should not be able to take far complications to reach their shop. Normally, Sushi Zanmai chooses to open their new outlet inside the shopping mall that those people visit regularly. Below as those outlets of Sushi Zanmai in Malaysia : †¢SUSHI ZANMAI, SUNWAY PIRAMID †¢SUSHI ZANMAI, LOW YAT PLAZA †¢SUSHI ZANMAI, 1 UTAMA †¢SUSHI ZANMAI, THE GARDENS MALL †¢SUSHI ZANMAI, FAHRENHEIT 88 †¢SUSHI ZANMAI, 1 M ONT’KIARA †¢SUSHI ZANMAI, PARADIGM MALL One of the outlets of Sushi Zanmai in K. L Distribution Sushi Zanmai’s distribution channel is a direct channel as they are selling their product directly to the customers. Their distribution channel is considered as a direct channel, and it is the best suitable method to do for selling sushi, udon and beverage to the customers. As Sushi Zanmai are being in food and beverage industry, the best way to serve their customers is by serving them nicely and directly. The shopkeepers who are preparing meal in front of the customers 5. 0 PROMOTION OF SUSHI ZANMAI Sushi Zanmai are using promotion methods which are Advertising and Sales Promotion. For advertising promotion purpose, they have created a web page over the internet that those people could get the information which about them with visiting their web page. Other than that, for the reasons of nowadays most of the people are having an account on facebook, so that they have created a facebook web page to be distributed among the facebook page. The facebook users or customers might do a feedback or recommendations that about them through their facebook page. Web page of Sushi Zanmai Sales promotional sets will be made to promote their products to let the customers try and enjoy their product and to create strong customer relationships by promoting personally and friendly service. Their popular promotional methods are: Have 50 % discounts for only these 4 types of items. The duration of this promotion is just for one week. Sushi Zanmai have did the promotion that shown as above. The customers will get a Chicken Karaage Don for only RM 6. 80 after finish the steps that set by them. Free RM 20 Sushi Zanmai voucher for those customers whom spend RM100 or above in any of their outlets. The duration for this voucher is just for one month. 6. 0 Improvements in 4p’strategies of Sushi Zanmai Product Sushi Zanmai should activate the strategy of product development and come up with new products from time to time as it is important to maintain the preference of the customers with the new developed products. For example, the organization can come up with new type of rice and new sushi flavour or developing new menu items in single orders such as Udon and etc. Place Shopping mall actually is a not bad idea for open a restaurant but also need to careful about the visibility. A restaurant that is located on a crowded place has high visibility. Conversely, a restaurant nestled on a not crowded place will always battle a disadvantage simply based on its location. Pricing Sushi Zanmai should be try not setting too higher price to attract more other guests purchase your product and also can earn more profit. Promotion Sushi Zanmai can also be improved by creating more value sets that prompts the customers to try out the new products made for specific period as a special promotion during particular season such as Valentine’ Day and Merry Christmas or holiday season value sets for example Advertising on TV Sushi Zanmai shoud has advertising on TV. Television is the most powerful advertising medium available. The largest corporations around the world use it to build their brands, bring customers, add credibility, and grow their businesses. Delivery Services Add delivery services. It can help a company gaining popularity and becoming more available. 7. 0 Conclusion In conclusion, i would like conclude by listing the 4p’strategies that regarding of is price, place, promotion and product. They are offering the combination of tangible goods and services in their business. In setting pricing the Sushi Zanmai is using price skimming for their products. For the place and distribution, The Sushi Zanmai is use direct as their channel. Moreover, the Therefore, Sushi Zanmai should improve its product quality and take considered action in order to improve the sales as expected.

Monday, October 14, 2019

How Important Is Home Stay To Thai Tourism Tourism Essay

How Important Is Home Stay To Thai Tourism Tourism Essay The purpose of this paper is to explore the importance of home stay accommodation to Thai tourism. The first concern of this paper is to identify the definition of home stay, identify the group of customers who like to use home stay accommodation in Thailand and also discover the activities that prove to be attractive to them. The second concern of this paper is that the development and expansion of a home stay destination should lead to advantages such as an increase in local income and employment opportunities. On the other hand, when too many tourists come to an unspoilt area it can have an adverse effect on the balance of natural ecology. For example, two places, namely Pai in Mae Hong Son province, one of the most popular home stay destinations in the North which is over developed , and Chiang Khan in Loei province, a developing home stay destination in the northeast of Thailand. Some people said that Chiang Khan is Pai of the past. Within Pai itself, there is a movement to resi st against the excesses that has spoilt Pai and destroyed its peaceful rural character that had drawn people to it in the first place. Thailand is a developing country that attempts to grow and tourism is an industry that can significantly help stimulate economic growth. Consequently, when home stay tourism improves, it will expand the power of supply and help draw more tourists. Therefore, sustainable development is the better way to balance the development and maintain the original character. Logically, the more travel destinations developed, the more tourists will come and the more money the country will earn. Keywords: Home stay, Thailand, Sustainable development Introduction Tourism makes a major contribution to Thailands economy. Most tourists come to Thailand for various reasons mostly for the beaches and relaxation. The friendly, easy-going ways of the Thai people also proves a draw to most tourists, as well as the rich Thai culture, customs and history. The new marketing slogan which was adopted in mid 2009, Amazing Thailand, Amazing Value, and the governments stimulation package also seemed to have helped reverse the downward trend for the latter half of 2009 and for the present year. Moreover, nowadays, most people are concerned about the effect of global warming and are returning to nature; in another word Green has become a new catchword for tourists. Not only Green but also Sustainable are the popular words more and more tourists are fanning out into the countryside to be closer to nature. Consequently, rural tourism makes use of the countryside as a destination. It is a significant sector of overall tourism market in many countries. It will affect not only the environment but also the economy and social structure of the countryside. The number of activities that tourists participate in has grown. For example, agri-tourism (agricultural, festivals and other cultural events), green tourism (considered to be more environmentally friendly) and ecotourism (nature tourism). Home stay is a part of rural tourism. In addition, sustainable tourism development is synonymous with rural tourism. Nowadays, home stay tourism in Thailand has become very popular for both dome stic and foreign tourists. Part of the reason may be due to the effect of the world economic crisis, with most tourists worrying about their budget and travelling in this kind of home stay tourism costs less. So, the Thai Government rapidly develop Thai home stay to meet this new demand for economical packages. But it can be a two-edged sword with both positive and negative sides. Therefore, we must find the right balance. Definition of Home stay Home stay is a form of tourism that allows the visitor to rent a room from a local family to stay and better learn the local lifestyle and share their culture. It is comparable to the western concept of bed and breakfasts. A home stay property is a non-commercialized, private residence that accommodates paying guest(s) who enjoy staying in the comfort and security of a family home. In Thailand, the history of home stay began with students who were volunteers for rural development camps and who stayed with the local people during the course of their camp. Then, National Economic and Social plan 8th emphasized the development of communities and decentralization to local areas and home stay had its first formal recognition. The attraction of home stay is the way of life of the local people and natural attractions are not always considered an essential part. There are two types of home stay in Thailand which are the original and practical. In the original home stay concept, tourists stay with the host and live under the same conditions as the owner. In the practical home stay, conditions are improved for more physical comfort but the concept of an easy way of life and unique culture is not abandoned. However, the significance of home stay is participation in community life in which local people manage activities together. The activities vary from place to place and according to seasonal variations. They may include Thai culinary, Thai massage, farm life etc. Moreover, OTOP (One tambon one product) is a concept whereby local people are encouraged to make local products for sale to boost their income. The owners are encouraged to think that each visitor is a guest, not just a tourist (tourismthailand.org). They are a part of the family. Home stay is just another job for the home owner. When tourists come he will extend them his welcome but he still retains his main job such as fisherman or farmer. The advantages of home stay are the local knowledge that will be gained from the host, understanding the easy way of life and experience the natural kindness of the local people. Moreover, the local people receive more income but they do not abandon their main job. In addition, they share the experience with the tourists, get more friends and the community can become strong. In the age of globalization, many people live in a competitive world so many people now want to explore the easy life and a life of simple sufficiency as an alternative way of life. An additional benefit of home stay accommodation is that most of the money earned goes to the grassroot local people, rather into a large conglomerate? The local home owners get most of the money paid by the tourists. This has a more substantial benefit to a community, rather that if a large hotel chain was to open a large hotel and merely employ local people as hotel staff. Most of the earnings will then go to the hotel chain, with most of it likely sent out of the country. The owner and accommodation should meet the standard of home stay in Thailand. The Tourism Authority of Thailand has set 10 standards and 31 indicators. Demand for home stay in Thailand The majority of income in Thailand comes from agriculture and tourism. Income from tourism is significant for the Thai economy in terms of expanding and stability of the economy. Tourism in Thailand caters both to domestic and foreign travelers. Nowadays, Thailand in faced with negative situations which decreased the confidence of tourists from 2008 until now. TAT expects the number of international tourists will grow at around 7 to 10% to approximately 15.0 to 15.5 million in 2010 (Tourism Authority of Thailand.com). The Bank of Thailand stated that there are 1.6 million foreign tourists who traveled to Thailand in February 2010 which represented a drop from last year. Domestic tourists were not particularly affected by the political situation. It was more influenced by the economic slowdown and fluctuating oil prices in the first and second quarters of 2009. Local travelers have changed their travelling habits, are more conscious of travel expenses, and are tending to visit tourist destinations closer to home (Tourism Authority of Thailand.com). The Office of the National Economic and Social Development Board predicted the economy would grow at 3 to 4% due to the global economic recovery and the governments Thai Khem Khaeng (Stronger Thailand) economic stimulus programme. New tourist attractions and activities that reflect the culture and style of a particular region will also be introduced. Therefore, the government supports and aims at the recovery of the Thai tourism market through marketing campaigns namely road shows to restore the image of Thailand and promotional advertisements under the Amazing Thailand, Amazing Value concept. Home stay is one of the better destinations which has proved attractive to both international and domestic tourists. It is a part of tourism in Thailand which continues to grow and earn income because it is set in rural areas far from the negative effects of political disturbances, is not expensive and brings visitors into close contact with nature. The tourists can relax among friendly local people. Therefore, the measurement and understanding of the demand and supply for tourism is important to overall tourism planning and management. We will know overall picture of the development, growth and value of tourism. All tourist behavior or activity results from motivation. Motivation is the context of the demand for tourism. Motivations have both push and pull factors together. The push factors are socio-psychological motives (person-specific factors). The pull factors are motives aroused by the destination (destination-specific factors). Tourists who go to home stay destinations usually have both push and pull factors. They want to relax, be close to nature and share knowledge, which are push factors. The pull factors are from the easy way of life of the people, unique culture and eco-friendliness. For example, a mini-farm is a magnet for tourists who travel with children. Mostly, domestic tourists usually go to home stay by car because some places are not far from urban centers such as Bangkok. It does not take too much time to immerse oneself in relaxation, fresh air and escape from the complicated city life. In contrast, international tourists mostly are backpackers usually stay a long time in home stays because of cheap prices but also because of the calmness, relaxed life style and the ability to e xplore new experience. Supply of the Home stay in Thailand On the supply side, the development of home stay is happening in Thailand. It is stimulated by the demand which comes from tourist needs. Some people want more comfort, some want plain, simple facilities, others demand higher standards. So, the local people work together toward the development of standards for home stay facilities in Thailand. Sometime, the popularity of a destination can lead to mass tourism. Mass tourism is a situation where a large number of tourists go to one place, sometime leading to an overload of local facilities. This can lead to further development of transport and other utilities until the easy way of life disappears. Moreover, it will adversely affect to the environment. Pai in Mae Hong Son province and Chiang Khan in Loei province are examples of popular home stay destinations in Thailand that have been developed to different degrees. One has already been spoilt and the other is resisting against a tendency toward over development. Pai is a small district in Mae Hong Son which was an ideal destination, being nestled in a small valley surrounded by mountains with cool weather. It was a romantic spot with friendly people can rich culture. Some people have referred to the village as called Uto-Pai, mimicking the name Utopia of Sir Thomas More. All this has made Pai very well known as hoards of tourists are drawn to it. Material development followed and soon the small village of Pai had its own air strip where tourists can arrive after a mere 25 minutes from Chiang Mai. Hotels and resorts also sprang up in its wake. All these development had a negative effect on the local inhabitant; while they used to be wont to retiring to bed early after a hard days work, they are now disturbed by loud music at entertainment places late at night. Music festivals became weekly events in the winter months. Some local people sold their land to capitalists and move to the foothills for the sake of peace and quiet. These changes reflect the fact that Pai is changing rapidly in both positive and negative ways. In addition, local children are falling to temptations from the western ways of tourists. Some local people said these development are more like deterioration. Not only Pai but Chiang Khan (a district on the bank of the Mekong river in Loei province), a relatively recent home stay destination, is facing similar problems. The conflict between local people and government is looming. The government wants to develop the town to cater to more and more tourists, but many local people want to see a steady growth of Chiang Khan. They want Chiang Khan to be strong, to retain its rural qualities and control itself. They do not want more bright lights in Chiang Khan, do not want to follow the modern trend because tourists come and go rapidly and do not stay a long time. Nowadays, some of the local people in Chiang Khan are already closing rank in a fight against rapidly over development. They have formed a tourism association within which they discussed the problems of westernization and over development which has plagued Pai. They have started a website where every one is welcomed to add comments. They are fighting against bright lights, loud music a nd weekend concerts that have combined to destroyed Pais rural character. They want tourism in Chiang Khan to be sustainable. They do not want Chiang Khan to have luxury boutique hotels, modern pubs or franchise coffee shop chains. They want Chiang Khan to retain its rural character with an easy way of life, home stays based on original houses without elaborate decoration, so when tourists come they will feel like they are the part of the family and coffee is still hand-brewed traditional coffee. Some people said that Chiang Khan is Pai of the past. Therefore, before Chiang Khan changes like Pai we must to help each other. Sustainable development of Home stay in Thailand Tourism, if developed locally, can help to ease the poverty problem, reduce income disparity and achieve a friendly environment as well as common prosperity. Tourism brings not only benefits but also costs and if not well managed may undermine its sustainability in the long run. In Thailand, tourism has a positive income generating effect but potentially worsening income distribution (Mingsan Kaosa-ard 2006). The best way to balance the development is through sustainable development in which every part must work together. Sustainable Development is development that satisfies the customer needs now but does not destroy tomorrows resources. The Pareto Optimum states that no one can be made better off by making someone worse off (businessdictionary.com). Customer demands lead to marketing research and material development. That is the marketing process. After that, planning and management are essential for achieving successful tourism development. Sustainable Tourism Development emphasizes the management of tourism industry must adapt itself according to the changing face of the world in term of sustainable pattern. There are three parameters of sustainability which are economic (well being), environment (ecological balance) and socio-cultural considerations (Sense of community and security). For example, the development should makes more money while at the same time have a minimum effect on the environment and social-cultural framework. The key to sustainable tourism development is to educate communities so that they understand the negative impacts of mass tourism and the limit to the ecosystems carrying capacity, and to develop diversified tourist products that can minimize the negative impact of mass tourism. For instance, in France they have standard and label for accommodation which confirm the standard and evaluate the standard and quality every five years. The label is one of marketing strategy which make good picture of the product. Moreover, they separate the demand equal in every areas and every part works together. Those are the good example for the development of home stay which Thailand should adapt for the development of home stay in Thailand. Amphawa floating market (Plai Pong Pag community) is a good example of home stay in Thailand which supports many tourists every year. It affects the quality of life of the local people, while the rapidly rising number of tourists has unavoidably led to a deterioration in the environment. Most of the home stay places have not attained the standard of home stay in Thailand even though this is the first community to launch the concept of home stay, but they have failed to meet the home stay standards. Because some home stay have transformed their homes so much that they became more like resorts and they do not match the qualifications of the home stay standard. Home stay will get the standard when they do not add more building and tourists must stay with the owner. According to that problem, National economic and social plan 9th stated that sustainable tourism in Thailand which wants to be a quality destination and ready in supply of tourism for support many tourists. We can transmit knowledge of France to Thailand; not in its entirety but we can adapt it. The government should have an effective and systemic plan such as setting policies or laws for the community and provide for penalties for culprits. It is hard for the government in Thailand to extend proper care to the home stay business in some communities because the local people worry about taxation and are not always forthcoming with information for the government. So, the government should establish an institute which can win the confidence of the local people and demonstrate the significance of the standard and effective management to the local people. The negative impacts on Pai and Chiang Khan happened because of civilization, but the impact on Amphawa was due to the ignorance of the local people. Therefore, the development is a two-edged sword that can have both advantages and disadvantages if we are ineffective. The best solution is the cooperation of everybody, beginning with community participation and the support of the government. The government decentralizes budgets to the community but continue to give technical advices to the local people. After that, policies such as the limit on the number of tourists will happen not only to care for the environment but for the sake of tourists who do not want to be in a place crowded with other tourists; they can relax and be closer to nature. Moreover, the local people can take care of all tourists like a part of the family. Do not forget that sustainable development is the better way of development and sustainable concern three things which are economy, environment and also socio-cu ltural parts. Conclusion In conclusion, tourism constitutes a major part of the Thai economy, encompassing both domestic and international tourists. Home stay is an alternative form of tourism which is based in the rural area that tourists stay and live with the local people. They can share the experience and culture. In Thailand, home stay began with the student volunteer for rural development camps and after National economic and social plan 8th home stay was developed until now. The motivations for travel home stay have both push and pull factors. The push factors usually are for relaxation. Mostly, domestic tourists go to home stay by car and relax for two or three days, but international tourists often stay much longer. The pull factors usually are the easy way of life, close contact with nature and fresh air. Material development is significant for home stay because it has both positive and negative sides. Material development can help attract tourists, although consideration must be given to suitable forms of development that should not destroy the original attraction of the place. It is a good marketing strategy to improve the quality of home stay accommodation. The home stay standards have been laid down in Thailand, but most of the home stays in Thailand still do not meet them, such as in Amphawa. Moreover, some places such as Pai is overloaded with tourists while Chiang Khan is still trying to resist this trend toward over-development. Pai and Chiang Khan demonstrate both advantages and disadvantages of material development. The solution for a balance is sustainability which centers on economic, environmental and socio-cultural considerations. France can be a good example for sustainable development. Thai home stay should adapt it and adopt it right now. The government should start by educating the local people and then carry out research on customer needs, marketing strategy, planning and management. In addition, strong policies are significant, with a need for penalties fo r those who break the rules. The importance is the cooperation of everybody in the country, because everybody is part of the progression of Thailand.